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Paper of The Month Mar 2014

Epidemic of Mumps among Vaccinated Persons, the Netherlands, 2009–2012.

Emerging Infectious Diseases. 2014. 20:4. 643-648.

Authors

Jussi Sane, Sigrid Gouma, Marion Koopmans, Hester de Melker, Corien Swaan, Rob van Binnendijk, and Susan Hahné

National Institute for Public Health and the Environment, Bilthoven, the Netherlands; European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden; and Erasmus Medical Centre, Rotterdam, the Netherlands.

Abstract

To analyze the epidemiology of a nationwide mumps epidemic in the Netherlands, we reviewed 1,557 notified mumps cases in persons who had disease onset during September 1, 2009–August 31, 2012. Seasonality peaked in spring and autumn. Most case-patients were males (59%), 18–25 years of age (67.9%), and vaccinated twice with mea- sles-mumps-rubella vaccine (67.7%). Nearly half (46.6%) of cases occurred in university students or in persons with student contacts. Receipt of 2 doses of vaccine reduced the risk for orchitis, the most frequently reported complication (vaccine effectiveness [VE] 74%, 95% CI 57%–85%); complications overall (VE 76%, 95% CI 61%–86%); and hospitalization (VE 82%, 95% CI 53%–93%). Over time, the age distribution of case-patients changed, and proportionally more cases were reported from non-university cities (p<0.001). Changes in age and geographic distribution over time may reflect increased immunity among students result- ing from intense exposure to circulating mumps virus.